Anticancer and Therapeutic Potential of Linum Usitatissimum Extract Against Pancreatic (Panc1) and Breast (MCF7) and Myeloid (HL60) Cancer Cells
autorzy: Baran Sharifi, Mahsa Shahbande
Plants have long been used to treat various diseases such as cancer due to their phytochemical and turquoise compounds. Linum usitatissimum (Linaceae) is one of the plants that has been used for centuries to prevent cancer. L. usitatissimum has been described as a strong anti-inflammatory, antibacterial, and analgesic. Also, the cytotoxicity of this plant has been proven due to its flavonoid compounds. The effect of medicinal plant extracts on cancer cell inhibition was investigated. Cytotoxic effect of L. usitatissimum extract on Panc-1, MCF7 and HL60 cancer cells was investigated by cell viability analysis, morphological changes, apoptosis induction. Results showed the cells treated with L. usitatissimum extract exhibited a considerable reduction in viability percent in comparison to control cells. Analysis of MTT demonstrated that the IC50 value of L. usitatissimum extract observed in 0.5 mg/mL for 48 h for all cancer cells. Also, morphological characteristics of cells indicated that L. usitatissimum extract induce cell death by apoptosis. Interestingly, in normal cells, no significant negative effect was observed as control.
Zdrowie / Medycyna / Fitness
Ochrona własności intelektualnej
Patent - przyznany
poziom gotowości technologicznej
TRL 6 skala pół przemysłowa