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Synthesizing Vinblastine from endophytic fungus Chaetomium nigricolor isolated from Catharanthus roseus

autorzy: Research Institute of Creative Education

Vinblastine is a popular ingredient used in cancer chemotherapy. However, this compound can only be biosynthesized from Catharanthus roseus and its endophytic fungi, thus, the price for drugs containing it is costly. In this research, a new solution for synthesizing Vinblastine has been found, lowering the price of drugs containing it by 20%. This is the first publication about Vinblastine extracted from Chaetomium nigricolor and the optimal solvent system to extract it in high concentration from this fungus.