Phytochemical and Alpha-glucosidase Inhibition Screening of Selected Plant Samples in San Francisco, Agusan Del Sur: Determination of Therapeutic Alternatives to Reduce Risks of Diabetes
autorzy: Michael Jee C. Concha Cavin Lloyd John D. Ranido Marie G. Labandero April Jewel L. Cariño Jonnelyn A. Simogan Kevynne P. De Guzman Hazzy Guin T. Olais Charles Glenn P. Mangadlao
This study aims to reduce diabetes prevalence in the country so, crude extracts of the collected samples in the locality undergone phytochemical analysis to identify bioactive compounds present and α-glucosidase inhibition assay where their inhibitory effect to produce glucose were detected through the absorbance in the Spetrophotometer. Results indicated bioactive compounds present in Bitan-ag (Kleinhovia hospita) –steroids; in Hagonoy (Chromolaena odorata) cardiac glycosides, steroids; in Costus speciosus saponins, steroids; in Gynura procumbens saponins, terpenoids; in Dumb cane (Dieffenbachia picta) phenolic compounds, steroids; and in Spondias dulcis tannins, saponins, terpenoids and flavonoids. Results further showed that there is significant difference between the treatments since the p-value is less than 0.05. The difference is between the alpha-glucosidase inhibitions of acarbose against the other treatments; there is no significant difference between the samples on their inhibitory activities. Dumb cane (Dieffenbachia picta) exhibited the highest percent inhibition among the plant samples with 22.98%. It is followed by Hagonoy (Chromonaela odorata) -18.28%, Bitan-ag (Kleinhovia hospita) – 13.78%, Costus speciosus – 13.44%, Gynura procumbens – 11.52% and Spondias dulcis – 9.07%. Therefore, the plant samples exhibited minimal inhibitory activity against alpha-glucosidase yet higher amount concentration has to be tested. These plant samples are not yet recommended for intake until further studies.
Środowisko / Chemia / Biotechnologia / Nanotechnologia
Ochrona własności intelektualnej
Patent - przyznany
poziom gotowości technologicznej
TRL 5 prototyp